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Malin Regulates Wnt Signaling Pathway through Degradation of Dishevelled2
Using yeast-two hybrid screening followed by co-immunoprecipitation assay, we have found that the Lafora disease ubiquitin ligase malin interacts with dishevelled2, a key mediator of Wnt signaling pathway. Overexpression of malin enhances the degradation of dishevelled2 and inhibits Wnt signaling, w...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3307269/ https://ncbi.nlm.nih.gov/pubmed/22223637 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.315135 |
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