Tannic Acid Is a Natural β-Secretase Inhibitor That Prevents Cognitive Impairment and Mitigates Alzheimer-like Pathology in Transgenic Mice

Amyloid precursor protein (APP) proteolysis is essential for production of amyloid-β (Aβ) peptides that form β-amyloid plaques in brains of Alzheimer disease (AD) patients. Recent focus has been directed toward a group of naturally occurring anti-amyloidogenic polyphenols known as flavonoids. We ora...

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Detalhes bibliográficos
Main Authors: Mori, Takashi, Rezai-Zadeh, Kavon, Koyama, Naoki, Arendash, Gary W., Yamaguchi, Haruyasu, Kakuda, Nobuto, Horikoshi-Sakuraba, Yuko, Tan, Jun, Town, Terrence
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3307267/
https://ncbi.nlm.nih.gov/pubmed/22219198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.294025
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