Methylene Blue Modulates β-Secretase, Reverses Cerebral Amyloidosis, and Improves Cognition in Transgenic Mice

Amyloid precursor protein (APP) proteolysis is required for production of amyloid-β (Aβ) peptides that comprise β-amyloid plaques in the brains of patients with Alzheimer disease (AD). Here, we tested whether the experimental agent methylene blue (MB), used for treatment of methemoglobinemia, might...

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Detalhes bibliográficos
Main Authors: Mori, Takashi, Koyama, Naoki, Segawa, Tatsuya, Maeda, Masahiro, Maruyama, Nobuhiro, Kinoshita, Noriaki, Hou, Huayan, Tan, Jun, Town, Terrence
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Neurobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4215215/
https://ncbi.nlm.nih.gov/pubmed/25157105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.568212
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