Methylene Blue Modulates β-Secretase, Reverses Cerebral Amyloidosis, and Improves Cognition in Transgenic Mice

Amyloid precursor protein (APP) proteolysis is required for production of amyloid-β (Aβ) peptides that comprise β-amyloid plaques in the brains of patients with Alzheimer disease (AD). Here, we tested whether the experimental agent methylene blue (MB), used for treatment of methemoglobinemia, might...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Mori, Takashi, Koyama, Naoki, Segawa, Tatsuya, Maeda, Masahiro, Maruyama, Nobuhiro, Kinoshita, Noriaki, Hou, Huayan, Tan, Jun, Town, Terrence
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2014
Soggetti:
Neurobiology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4215215/
https://ncbi.nlm.nih.gov/pubmed/25157105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.568212
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi