Methylene Blue Modulates β-Secretase, Reverses Cerebral Amyloidosis, and Improves Cognition in Transgenic Mice

Amyloid precursor protein (APP) proteolysis is required for production of amyloid-β (Aβ) peptides that comprise β-amyloid plaques in the brains of patients with Alzheimer disease (AD). Here, we tested whether the experimental agent methylene blue (MB), used for treatment of methemoglobinemia, might...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Asıl Yazarlar: Mori, Takashi, Koyama, Naoki, Segawa, Tatsuya, Maeda, Masahiro, Maruyama, Nobuhiro, Kinoshita, Noriaki, Hou, Huayan, Tan, Jun, Town, Terrence
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2014
Konular:
Neurobiology
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4215215/
https://ncbi.nlm.nih.gov/pubmed/25157105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.568212
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!

Benzer Materyaller