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Effects of single-nucleotide polymorphisms in the human holocarboxylase synthetase gene on enzyme catalysis
Holocarboxylase synthetase (HLCS) is a biotin protein ligase, which has a pivotal role in biotin-dependent metabolic pathways and epigenetic phenomena in humans. Knockdown of HLCS produces phenotypes such as heat susceptibility and decreased life span in Drosophila melanogaster, whereas knockout of...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2012
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3306849/ https://ncbi.nlm.nih.gov/pubmed/22027809 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ejhg.2011.198 |
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