Association of IREB2 and CHRNA3 polymorphisms with airflow obstruction in severe alpha-1 antitrypsin deficiency

BACKGROUND: The development of COPD in subjects with alpha-1 antitrypsin (AAT) deficiency is likely to be influenced by modifier genes. Genome-wide association studies and integrative genomics approaches in COPD have demonstrated significant associations with SNPs in the chromosome 15q region that i...

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Hauptverfasser: Kim, Woo Jin, Wood, Alice M, Barker, Alan F, Brantly, Mark L, Campbell, Edward J, Eden, Edward, McElvaney, Gerard, Rennard, Stephen I, Sandhaus, Robert A, Stocks, James M, Stoller, James K, Strange, Charlie, Turino, Gerard, Silverman, Edwin K, Stockley, Robert A, DeMeo, Dawn L
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2012
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3306733/
https://ncbi.nlm.nih.gov/pubmed/22356581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1465-9921-13-16
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