Association of IREB2 and CHRNA3 polymorphisms with airflow obstruction in severe alpha-1 antitrypsin deficiency

BACKGROUND: The development of COPD in subjects with alpha-1 antitrypsin (AAT) deficiency is likely to be influenced by modifier genes. Genome-wide association studies and integrative genomics approaches in COPD have demonstrated significant associations with SNPs in the chromosome 15q region that i...

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Main Authors: Kim, Woo Jin, Wood, Alice M, Barker, Alan F, Brantly, Mark L, Campbell, Edward J, Eden, Edward, McElvaney, Gerard, Rennard, Stephen I, Sandhaus, Robert A, Stocks, James M, Stoller, James K, Strange, Charlie, Turino, Gerard, Silverman, Edwin K, Stockley, Robert A, DeMeo, Dawn L
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2012
Assuntos:
Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3306733/
https://ncbi.nlm.nih.gov/pubmed/22356581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1465-9921-13-16
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