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Association of IREB2 and CHRNA3 polymorphisms with airflow obstruction in severe alpha-1 antitrypsin deficiency

BACKGROUND: The development of COPD in subjects with alpha-1 antitrypsin (AAT) deficiency is likely to be influenced by modifier genes. Genome-wide association studies and integrative genomics approaches in COPD have demonstrated significant associations with SNPs in the chromosome 15q region that i...

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Bibliografische gegevens
Hoofdauteurs: Kim, Woo Jin, Wood, Alice M, Barker, Alan F, Brantly, Mark L, Campbell, Edward J, Eden, Edward, McElvaney, Gerard, Rennard, Stephen I, Sandhaus, Robert A, Stocks, James M, Stoller, James K, Strange, Charlie, Turino, Gerard, Silverman, Edwin K, Stockley, Robert A, DeMeo, Dawn L
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2012
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3306733/
https://ncbi.nlm.nih.gov/pubmed/22356581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1465-9921-13-16
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