Association of cigarette smoking and CRP levels with DNA methylation in α-1 antitrypsin deficiency

Alpha-1 antitrypsin (AAT) deficiency and tobacco smoking are confirmed risk factors for Chronic Obstructive Pulmonary Disease. We hypothesized that variable DNA methylation would be associated with smoking and inflammation, as reflected by the level of C-Reactive Protein (CRP) in AAT-deficient subje...

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Autori principali: Siedlinski, Mateusz, Klanderman, Barbara, Sandhaus, Robert A., Barker, Alan F., Brantly, Mark L., Eden, Edward, McElvaney, N. Gerard, Rennard, Stephen I., Stocks, James M., Stoller, James K., Strange, Charlie, Turino, Gerard M., Campbell, Edward J., DeMeo, Dawn L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Landes Bioscience 2012
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3414392/
https://ncbi.nlm.nih.gov/pubmed/22617718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/epi.20319
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