Failure of Iniparib to Inhibit Poly(ADP-ribose) Polymerase in Vitro

PURPOSE: Poly(ADP-ribose) polymerase (PARP) inhibitors are undergoing extensive clinical testing for their single-agent activity in homologous recombination- (HR-) deficient tumors and ability to enhance the action of certain DNA damaging agents. Compared to other PARP inhibitors in development, ini...

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Bibliografiske detaljer
Main Authors: Patel, Anand G., De Lorenzo, Silvana, Flatten, Karen S., Poirier, Guy G., Kaufmann, Scott H.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3306513/
https://ncbi.nlm.nih.gov/pubmed/22291137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-11-2890
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