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Nonhomologous end joining drives poly(ADP-ribose) polymerase (PARP) inhibitor lethality in homologous recombination-deficient cells

Poly(ADP-ribose) polymerase (PARP) inhibitors are strikingly toxic to cells with defects in homologous recombination (HR). The mechanistic basis for these findings is incompletely understood. Here, we show that PARP inhibitor treatment induces phosphorylation of DNA-dependent protein kinase substrat...

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書誌詳細
主要な著者: Patel, Anand G., Sarkaria, Jann N., Kaufmann, Scott H.
フォーマット: Artigo
言語:Inglês
出版事項: National Academy of Sciences 2011
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3044391/
https://ncbi.nlm.nih.gov/pubmed/21300883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1013715108
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