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Arg375 Tunes Tetrahydrobiopterin Functions and Modulates Catalysis by Inducible Nitric Oxide Synthase
NO synthase enzymes (NOS) support unique single-electron transitions of a bound H(4)B cofactor during catalysis. Previous studies showed that both the pterin structure and surrounding protein residues impact H(4)B redox function during catalysis. A conserved Arg residue (Arg375 in iNOS) forms hydrog...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3306459/ https://ncbi.nlm.nih.gov/pubmed/22173094 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jinorgbio.2011.11.015 |
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