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Tetrahydrobiopterin Redox Cycling in Nitric-oxide Synthase: Evidence Supports a Through-Heme Electron Delivery
The NO synthases (NOS) catalyze a two-step oxidation of L-Arginine (Arg) to generate NO. In the first step, O(2) activation involves one electron being provided to the heme by an enzyme-bound 6R-tetrahydro-L-biopterin cofactor (H(4)B), which then forms a H(4)B radical that must be reduced back to H(...
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| Veröffentlicht in: | FEBS J |
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| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5387691/ https://ncbi.nlm.nih.gov/pubmed/27760279 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/febs.13933 |
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