Naloxone inhibits immune cell function by suppressing superoxide production through a direct interaction with gp91(phox )subunit of NADPH oxidase

BACKGROUND: Both (-) and (+)-naloxone attenuate inflammation-mediated neurodegeneration by inhibition of microglial activation through superoxide reduction in an opioid receptor-independent manner. Multiple lines of evidence have documented a pivotal role of overactivated NADPH oxidase (NOX2) in inf...

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Bibliographische Detailangaben
Hauptverfasser: Wang, Qingshan, Zhou, Hui, Gao, Huiming, Chen, Shih-Heng, Chu, Chun-Hsien, Wilson, Belinda, Hong, Jau-Shyong
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2012
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3305409/
https://ncbi.nlm.nih.gov/pubmed/22340895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-9-32
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