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Naloxone inhibits immune cell function by suppressing superoxide production through a direct interaction with gp91(phox )subunit of NADPH oxidase
BACKGROUND: Both (-) and (+)-naloxone attenuate inflammation-mediated neurodegeneration by inhibition of microglial activation through superoxide reduction in an opioid receptor-independent manner. Multiple lines of evidence have documented a pivotal role of overactivated NADPH oxidase (NOX2) in inf...
Tallennettuna:
| Päätekijät: | , , , , , , |
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| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
BioMed Central
2012
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3305409/ https://ncbi.nlm.nih.gov/pubmed/22340895 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-9-32 |
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