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Rational Design and Evaluation of Mammalian Ribonuclease Cytotoxins
Mammalian pancreatic-type ribonucleases (ptRNases) comprise an enzyme family that is remarkably well suited for therapeutic exploitation. ptRNases are robust and prodigious catalysts of RNA cleavage that can naturally access the cytosol. Instilling cytotoxic activity requires endowing them with the...
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| Autores principales: | , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2012
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3304445/ https://ncbi.nlm.nih.gov/pubmed/22208989 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/B978-0-12-416039-2.00014-8 |
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