Influence of paraoxonase-1 Q192R and cytochrome P450 2C19 polymorphisms on clopidogrel response

BACKGROUND: The metabolic activation of clopidogrel is a two-step process. It has been suggested that paraoxonase-1 (PON1) is a rate-limiting enzyme in the conversion of 2-oxo- clopidogrel to an active thiol metabolite. Conflicting results have been reported in regard to (1) the association of a com...

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Bibliographic Details
Main Authors: Kreutz, Rolf P, Nystrom, Perry, Kreutz, Yvonne, Miao, Jia, Desta, Zeruesenay, Breall, Jeffrey A, Li, Lang, Chiang, ChienWei, Kovacs, Richard, Flockhart, David A, Jin, Yan
Format: Artigo
Language:Inglês
Published: Dove Medical Press 2012
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Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3304338/
https://ncbi.nlm.nih.gov/pubmed/22427735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/CPAA.S27822
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