Inhibition of platelet aggregation by prostaglandin E1 (PGE1) in diabetic patients during therapy with clopidogrel and aspirin

Diabetes mellitus (DM) is associated with increased platelet activation and reduced platelet inhibition by clopidogrel. Prostaglandin E1 (PGE1) stimulates adenyl cyclase activity in platelets and increases cyclic AMP concentrations, which inhibit Ca(2+)release and platelet aggregation induced by P2Y...

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Main Authors: KREUTZ, ROLF P., NYSTROM, PERRY, KREUTZ, YVONNE, MIAO, JIA, KOVACS, RICHARD, DESTA, ZERUESENAY, FLOCKHART, DAVID A., JIN, YAN
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4028123/
https://ncbi.nlm.nih.gov/pubmed/22385219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/09537104.2012.661107
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