Inhibition of platelet aggregation by prostaglandin E1 (PGE1) in diabetic patients during therapy with clopidogrel and aspirin

Diabetes mellitus (DM) is associated with increased platelet activation and reduced platelet inhibition by clopidogrel. Prostaglandin E1 (PGE1) stimulates adenyl cyclase activity in platelets and increases cyclic AMP concentrations, which inhibit Ca(2+)release and platelet aggregation induced by P2Y...

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Main Authors: KREUTZ, ROLF P., NYSTROM, PERRY, KREUTZ, YVONNE, MIAO, JIA, KOVACS, RICHARD, DESTA, ZERUESENAY, FLOCKHART, DAVID A., JIN, YAN
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2012
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4028123/
https://ncbi.nlm.nih.gov/pubmed/22385219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/09537104.2012.661107
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