Protease Activated Receptor-1 (PAR-1) Mediated Platelet Aggregation is Dependant on Clopidogrel Response

INTRODUCTION: Clopidogrel inhibits ADP mediated platelet aggregation through inhibition of the P2Y12 receptor by its active metabolite. Thrombin induces platelet aggregation by binding to protease activated receptor-1 (PAR-1), and inhibition of PAR-1 has been evaluated in patients treated with clopi...

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Huvudupphovsmän: Kreutz, Rolf P., Breall, Jeffrey A., Kreutz, Yvonne, Owens, Janelle, Lu, Deshun, Bolad, Islam, von der Lohe, Elisabeth, Sinha, Anjan, Flockhart, David A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2012
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3965578/
https://ncbi.nlm.nih.gov/pubmed/22459907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.thromres.2012.02.049
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