Generation and exploration of new classes of antitubercular agents: The optimization of oxazolines, oxazoles, thiazolines, thiazoles to imidazo[1,2-a]pyridines and isomeric 5,6-fused scaffolds

Tuberculosis (TB) is a devastating disease resulting in a death every 20 seconds. Thus, new drugs are urgently needed. Herein we report ten classes of compounds—oxazoline, oxazole, thiazoline, thiazole, pyrazole, pyridine, isoxazole, imidazo[1,2-a]pyridine, imidazo[1,2-a]pyrimidine and imidazo[1,2-c...

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Hlavní autoři: Moraski, Garrett C., Markley, Lowell D., Chang, Mayland, Cho, Sanghyun, Franzblau, Scott G., Hwang, Chang Hwa, Boshoff, Helena, Miller, Marvin J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3304000/
https://ncbi.nlm.nih.gov/pubmed/22391032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2012.02.025
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