Analysis of Hepatitis C Virus Intrahost Diversity across the Coding Region by Ultradeep Pyrosequencing

Hepatitis C virus (HCV) is the leading cause of liver disease worldwide. In this study, we analyzed four treatment-naïve patients infected with subtype 1a and performed Roche/454 pyrosequencing across the coding region. We report the presence of low-level drug resistance mutations that would most li...

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Autori principali: Lauck, Michael, Alvarado-Mora, Mónica V., Becker, Ericka A., Bhattacharya, Dipankar, Striker, Rob, Hughes, Austin L., Carrilho, Flair J., O'Connor, David H., Pinho, João R. Rebello
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2012
Soggetti:
Genetic Diversity and Evolution
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3302523/
https://ncbi.nlm.nih.gov/pubmed/22278255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.06627-11
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