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SIV Genome-Wide Pyrosequencing Provides a Comprehensive and Unbiased View of Variation within and outside CD8 T Lymphocyte Epitopes

Deep sequencing technology is revolutionizing our understanding of HIV/SIV evolution. It is known that acute SIV sequence variation within CD8 T lymphocyte (CD8-TL) epitopes is similar among MHC-identical animals, but we do not know whether this persists into the chronic phase. We now determine whet...

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Detalhes bibliográficos
Main Authors: Hughes, Austin L., Becker, Ericka A., Lauck, Michael, Karl, Julie A., Braasch, Andrew T., O’Connor, David H., O’Connor, Shelby L.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3480401/
https://ncbi.nlm.nih.gov/pubmed/23112852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0047818
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