The Multibasic Cleavage Site of the Hemagglutinin of Highly Pathogenic A/Vietnam/1203/2004 (H5N1) Avian Influenza Virus Acts as a Virulence Factor in a Host-Specific Manner in Mammals

Highly pathogenic avian influenza (HPAI) viruses of the H5 and H7 subtypes typically possess multiple basic amino acids around the cleavage site (MBS) of their hemagglutinin (HA) protein, a recognized virulence motif in poultry. To determine the importance of the H5 HA MBS as a virulence factor in m...

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Detalhes bibliográficos
Main Authors: Suguitan, Amorsolo L., Matsuoka, Yumiko, Lau, Yuk-Fai, Santos, Celia P., Vogel, Leatrice, Cheng, Lily I., Orandle, Marlene, Subbarao, Kanta
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3302284/
https://ncbi.nlm.nih.gov/pubmed/22205751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.05546-11
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