The Matrix Gene Segment Destabilizes the Acid and Thermal Stability of the Hemagglutinin of Pandemic Live Attenuated Influenza Virus Vaccines

The threat of future influenza pandemics and their potential for rapid spread, morbidity, and mortality has led to the development of pandemic vaccines. We generated seven reassortant pandemic live attenuated influenza vaccines (pLAIVs) with the hemagglutinin (HA) and neuraminidase (NA) genes derive...

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Vydáno v:J Virol
Hlavní autoři: O'Donnell, Christopher D., Vogel, Leatrice, Matsuoka, Yumiko, Jin, Hong, Subbarao, Kanta
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2014
Témata:
Vaccines and Antiviral Agents
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4248896/
https://ncbi.nlm.nih.gov/pubmed/25122789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01107-14
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