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Glycosylation at 158N of the Hemagglutinin Protein and Receptor Binding Specificity Synergistically Affect the Antigenicity and Immunogenicity of a Live Attenuated H5N1 A/Vietnam/1203/2004 Vaccine Virus in Ferrets

A live attenuated influenza A/Vietnam/1203/2004 (H5N1) vaccine virus (VN04 ca) has receptor binding specificity to α2,3-linked sialosides (α2,3SAL), and a single dose induces a minimal serum antibody response in mice and ferrets. In contrast, A/Hong Kong/213/2003 (H5N1) vaccine virus (HK03 ca) binds...

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Detalhes bibliográficos
Main Authors: Wang, Weijia, Lu, Bin, Zhou, Helen, Suguitan, Amorsolo L., Cheng, Xing, Subbarao, Kanta, Kemble, George, Jin, Hong
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2903256/
https://ncbi.nlm.nih.gov/pubmed/20427525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00221-10
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