Experimental and/or genetically controlled alterations of the renal microsomal cytochrome P450 epoxygenase induce hypertension in rats fed a high salt diet.

Excess dietary salt induces a cytochrome P450 arachidonic acid epoxygenase isoform in rat kidneys (Capdevila, J. H., S. Wei, J. Yang, A. Karara, H. R. Jacobson, J. R. Falck, F. P. Guengerich, and R. N. Dubois. 1992. J. Biol. Chem. 267:21720-21726). Treatment of rats on a high salt diet with the epox...

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Publié dans:	J Clin Invest
Auteurs principaux:	Makita, K, Takahashi, K, Karara, A, Jacobson, H R, Falck, J R, Capdevila, J H
Format:	Artigo
Langue:	Inglês
Publié:	American Society for Clinical Investigation 1994
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC330072/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7989598/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI117608
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