Experimental and/or genetically controlled alterations of the renal microsomal cytochrome P450 epoxygenase induce hypertension in rats fed a high salt diet.

Excess dietary salt induces a cytochrome P450 arachidonic acid epoxygenase isoform in rat kidneys (Capdevila, J. H., S. Wei, J. Yang, A. Karara, H. R. Jacobson, J. R. Falck, F. P. Guengerich, and R. N. Dubois. 1992. J. Biol. Chem. 267:21720-21726). Treatment of rats on a high salt diet with the epox...

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Dades bibliogràfiques
Publicat a:J Clin Invest
Autors principals: Makita, K, Takahashi, K, Karara, A, Jacobson, H R, Falck, J R, Capdevila, J H
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 1994
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC330072/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7989598/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI117608
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