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Native gel electrophoresis of human telomerase distinguishes active complexes with or without dyskerin

Telomeres, the ends of linear chromosomes, safeguard against genome instability. The enzyme responsible for extension of the telomere 3′ terminus is the ribonucleoprotein telomerase. Whereas telomerase activity can be reconstituted in vitro with only the telomerase RNA (hTR) and telomerase reverse t...

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Detalhes bibliográficos
Main Authors: Gardano, Laura, Holland, Linda, Oulton, Rena, Le Bihan, Thierry, Harrington, Lea
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3300002/
https://ncbi.nlm.nih.gov/pubmed/22187156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr1243
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