Stimulators and Activators of Soluble Guanylate Cyclase: Review and Potential Therapeutic Indications

The heme-protein soluble guanylyl cyclase (sGC) is the intracellular receptor for nitric oxide (NO). sGC is a heterodimeric enzyme with α and β subunits and contains a heme moiety essential for binding of NO and activation of the enzyme. Stimulation of sGC mediates physiologic responses including sm...

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Main Authors: Nossaman, Bobby, Pankey, Edward, Kadowitz, Philip
Format: Artigo
Jezik:Inglês
Izdano: Hindawi Publishing Corporation 2012
Teme:
Review Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3299283/
https://ncbi.nlm.nih.gov/pubmed/22482042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/290805
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