Dissecting the role of the mitochondrial chaperone mortalin in Parkinson's disease: functional impact of disease-related variants on mitochondrial homeostasis

The mitochondrial chaperone mortalin has been linked to neurodegeneration in Parkinson's disease (PD) based on reduced protein levels in affected brain regions of PD patients and its interaction with the PD-associated protein DJ-1. Recently, two amino acid exchanges in the ATPase domain (R126W)...

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Bibliografiske detaljer
Main Authors: Burbulla, Lena F., Schelling, Carina, Kato, Hiroki, Rapaport, Doron, Woitalla, Dirk, Schiesling, Carola, Schulte, Claudia, Sharma, Manu, Illig, Thomas, Bauer, Peter, Jung, Stephan, Nordheim, Alfred, Schöls, Ludger, Riess, Olaf, Krüger, Rejko
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2010
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3298849/
https://ncbi.nlm.nih.gov/pubmed/20817635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddq370
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