Mitochondrial proteolytic stress induced by loss of mortalin function is rescued by Parkin and PINK1

The mitochondrial chaperone mortalin was implicated in Parkinson's disease (PD) because of its reduced levels in the brains of PD patients and disease-associated rare genetic variants that failed to rescue impaired mitochondrial integrity in cellular knockdown models. To uncover the molecular m...

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Detalhes bibliográficos
Main Authors: Burbulla, L F, Fitzgerald, J C, Stegen, K, Westermeier, J, Thost, A-K, Kato, H, Mokranjac, D, Sauerwald, J, Martins, L M, Woitalla, D, Rapaport, D, Riess, O, Proikas-Cezanne, T, Rasse, T M, Krüger, R
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4001296/
https://ncbi.nlm.nih.gov/pubmed/24743735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.103
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