Dissecting the role of the mitochondrial chaperone mortalin in Parkinson's disease: functional impact of disease-related variants on mitochondrial homeostasis

The mitochondrial chaperone mortalin has been linked to neurodegeneration in Parkinson's disease (PD) based on reduced protein levels in affected brain regions of PD patients and its interaction with the PD-associated protein DJ-1. Recently, two amino acid exchanges in the ATPase domain (R126W)...

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Detalhes bibliográficos
Main Authors: Burbulla, Lena F., Schelling, Carina, Kato, Hiroki, Rapaport, Doron, Woitalla, Dirk, Schiesling, Carola, Schulte, Claudia, Sharma, Manu, Illig, Thomas, Bauer, Peter, Jung, Stephan, Nordheim, Alfred, Schöls, Ludger, Riess, Olaf, Krüger, Rejko
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2010
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3298849/
https://ncbi.nlm.nih.gov/pubmed/20817635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddq370
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