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Modeling the Binding of Three Toxins to the Voltage-Gated Potassium Channel (Kv1.3)

The conduction properties of the voltage-gated potassium channel Kv1.3 and its modes of interaction with several polypeptide venoms are examined using Brownian dynamics simulations and molecular dynamics calculations. Employing an open-state homology model of Kv1.3, we first determine current-voltag...

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Autors principals: Chen, Rong, Robinson, Anna, Gordon, Dan, Chung, Shin-Ho
Format: Artigo
Idioma:Inglês
Publicat: The Biophysical Society 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3297799/
https://ncbi.nlm.nih.gov/pubmed/22261053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2011.10.029
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