The Loop 5 Element Structurally and Kinetically Coordinates Dimers of the Human Kinesin-5, Eg5

Eg5 is a homotetrameric kinesin-5 motor protein that generates outward force on the overlapping, antiparallel microtubules (MTs) of the mitotic spindle. Upon binding an MT, an Eg5 dimer releases one ADP molecule, undergoes a slow (∼0.5 s(−1)) isomerization, and finally releases a second ADP, adoptin...

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Autori principali: Waitzman, Joshua S., Larson, Adam G., Cochran, Jared C., Naber, Nariman, Cooke, Roger, Kull, F. Jon, Pate, Edward, Rice, Sarah E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Biophysical Society 2011
Soggetti:
Muscle, Motility, and Motor Proteins
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3297777/
https://ncbi.nlm.nih.gov/pubmed/22261065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2011.10.032
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