The Conserved L5 Loop Establishes the Pre-Powerstroke Conformation of the Kinesin-5 Motor, Eg5

Kinesin superfamily motor proteins contain a structurally conserved loop near the ATP binding site, termed L5. The function of L5 is unknown, although several drug inhibitors of the mitotic kinesin Eg5 bind to L5. We used electron paramagnetic resonance spectroscopy (EPR) to investigate the function...

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Detalhes bibliográficos
Main Authors: Larson, Adam G., Naber, Nariman, Cooke, Roger, Pate, Edward, Rice, Sarah E.
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2010
Assuntos:
Muscle, Motility, and Motor Proteins
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2877332/
https://ncbi.nlm.nih.gov/pubmed/20513406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2010.03.014
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