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Recombinant human enkephalinase (neutral endopeptidase) prevents cough induced by tachykinins in awake guinea pigs.

To determine whether recombinant enkephalinase (neutral endopeptidase, EC 3.4.24.11) prevents cough induced by exogenously applied and endogenously released neuropeptides, we measured cough responses to aerosolized solutions of substance P or of capsaicin for 2 min in random-source guinea pigs befor...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Principais autores: Kohrogi, H, Nadel, J A, Malfroy, B, Gorman, C, Bridenbaugh, R, Patton, J S, Borson, D B
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 1989
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC329719/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2474575/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI114236
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