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Recombinant human enkephalinase (neutral endopeptidase) prevents cough induced by tachykinins in awake guinea pigs.

To determine whether recombinant enkephalinase (neutral endopeptidase, EC 3.4.24.11) prevents cough induced by exogenously applied and endogenously released neuropeptides, we measured cough responses to aerosolized solutions of substance P or of capsaicin for 2 min in random-source guinea pigs befor...

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Bibliografiske detaljer
Udgivet i:J Clin Invest
Principais autores: Kohrogi, H, Nadel, J A, Malfroy, B, Gorman, C, Bridenbaugh, R, Patton, J S, Borson, D B
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 1989
Fag:
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC329719/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2474575/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI114236
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