Toluene diisocyanate increases airway responsiveness to substance P and decreases airway neutral endopeptidase.

Substance P and related tachykinins contribute to the airway hyperresponsiveness caused by toluene diisocyanate (TDI) in guinea pigs. Neutral endopeptidase (NEP) is an important modulator of substance P-induced responses. To test the hypothesis that exposure to TDI would increase responsiveness to s...

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Detalhes bibliográficos

Publicado no:	J Clin Invest
Principais autores:	Sheppard, D, Thompson, J E, Scypinski, L, Dusser, D, Nadel, J A, Borson, D B
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 1988
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC329638/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2450892/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI113424
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