Toluene diisocyanate increases airway responsiveness to substance P and decreases airway neutral endopeptidase.
Substance P and related tachykinins contribute to the airway hyperresponsiveness caused by toluene diisocyanate (TDI) in guinea pigs. Neutral endopeptidase (NEP) is an important modulator of substance P-induced responses. To test the hypothesis that exposure to TDI would increase responsiveness to s...
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| Published in: | J Clin Invest |
|---|---|
| Main Authors: | , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
American Society for Clinical Investigation
1988
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC329638/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2450892/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI113424 |
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