Extracellular protons acidify osteoclasts, reduce cytosolic calcium, and promote expression of cell-matrix attachment structures.

Because metabolic acids stimulate bone resorption in vitro and in vivo, we focused on the cellular events produced by acidosis that might be associated with stimulation of bone remodeling. To this end, we exposed isolated chicken osteoclasts to a metabolic (butyric) acid and observed a fall in both...

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Publikašuvnnas:	J Clin Invest
Váldodahkkit:	Teti, A, Blair, H C, Schlesinger, P, Grano, M, Zambonin-Zallone, A, Kahn, A J, Teitelbaum, S L, Hruska, K A
Materiálatiipa:	Artigo
Giella:	Inglês
Almmustuhtton:	American Society for Clinical Investigation 1989
Fáttát:	Research Article
Liŋkkat:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC329718/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2547838/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI114235
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