Extracellular protons acidify osteoclasts, reduce cytosolic calcium, and promote expression of cell-matrix attachment structures.

Because metabolic acids stimulate bone resorption in vitro and in vivo, we focused on the cellular events produced by acidosis that might be associated with stimulation of bone remodeling. To this end, we exposed isolated chicken osteoclasts to a metabolic (butyric) acid and observed a fall in both...

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Detalhes bibliográficos

Publicado no:	J Clin Invest
Principais autores:	Teti, A, Blair, H C, Schlesinger, P, Grano, M, Zambonin-Zallone, A, Kahn, A J, Teitelbaum, S L, Hruska, K A
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 1989
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC329718/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2547838/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI114235
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