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Total Synthesis of (+)-Scholarisine A

An effective total synthesis and assignment of the absolute configuration of the architecturally challenging (+)-scholarisine A has been achieved via a 20-step sequence. Highlights include a reductive cyclization, involving a nitrile and an epoxide; a modified Fischer indole protocol; a late stage o...

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Detalhes bibliográficos
Main Authors: Adams, Gregory L., Carroll, Patrick J., Smith, Amos B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3296875/
https://ncbi.nlm.nih.gov/pubmed/22280070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja211840k
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