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Destabilizing Domains Derived from the Human Estrogen Receptor

Methods to rapidly and reversibly perturb the functions of specific proteins are desirable tools for studies of complex biological processes. We have demonstrated an experimental strategy to regulate the intracellular concentration of any protein of interest by using an engineered destabilizing prot...

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Autori principali: Miyazaki, Yusuke, Imoto, Hiroshi, Chen, Ling-chun, Wandless, Thomas J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3296833/
https://ncbi.nlm.nih.gov/pubmed/22332638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja209933r
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