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Molecular mechanism of pharmacological activation of BK channels

Large-conductance voltage- and Ca(2+)-activated K(+) (Slo1 BK) channels serve numerous cellular functions, and their dysregulation is implicated in various diseases. Drugs activating BK channels therefore bear substantial therapeutic potential, but their deployment has been hindered in part because...

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Detalhes bibliográficos
Main Authors: Gessner, Guido, Cui, Yong-Mei, Otani, Yuko, Ohwada, Tomohiko, Soom, Malle, Hoshi, Toshinori, Heinemann, Stefan H.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3295268/
https://ncbi.nlm.nih.gov/pubmed/22331907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1114321109
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