Crystallographic basis for calcium regulation of sodium channels

Voltage-gated sodium channels underlie the rapid regenerative upstroke of action potentials and are modulated by cytoplasmic calcium ions through a poorly understood mechanism. We describe the 1.35 Å crystal structure of Ca(2+)-bound calmodulin (Ca(2+)/CaM) in complex with the inactivation gate (DII...

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Bibliografiske detaljer
Main Authors: Sarhan, Maen F., Tung, Ching-Chieh, Van Petegem, Filip, Ahern, Christopher A.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2012
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3295267/
https://ncbi.nlm.nih.gov/pubmed/22331908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1114748109
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