New Mutations at the Imprinted Gnas Cluster Show Gene Dosage Effects of Gsα in Postnatal Growth and Implicate XLαs in Bone and Fat Metabolism but Not in Suckling

The imprinted Gnas cluster is involved in obesity, energy metabolism, feeding behavior, and viability. Relative contribution of paternally expressed proteins XLαs, XLN1, and ALEX or a double dose of maternally expressed Gsα to phenotype has not been established. In this study, we have generated two...

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Main Authors: Eaton, Sally A., Williamson, Christine M., Ball, Simon T., Beechey, Colin V., Moir, Lee, Edwards, Jessica, Teboul, Lydia, Maconochie, Mark, Peters, Jo
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2012
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3295192/
https://ncbi.nlm.nih.gov/pubmed/22215617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.06174-11
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