Antisense Activity across the Nesp Promoter is Required for Nespas-Mediated Silencing in the Imprinted Gnas Cluster

Macro long non-coding RNAs (lncRNAs) play major roles in gene silencing in inprinted gene clusters. Within the imprinted Gnas cluster, the paternally expressed Nespas lncRNA downregulates its sense counterpart Nesp. To explore the mechanism of action of Nespas, we generated two new knock-in alleles...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Noncoding RNA
Egile Nagusiak: Tibbit, Charlotte J., Williamson, Christine M., Mehta, Stuti, Ball, Simon T., Chotalia, Mita, Nottingham, Wade T., Eaton, Sally A., Quwailid, Mohamed M., Teboul, Lydia, Kelsey, Gavin, Peters, Jo
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: MDPI 2015
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5932550/
https://ncbi.nlm.nih.gov/pubmed/29861426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ncrna1030246
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