Antisense Activity across the Nesp Promoter is Required for Nespas-Mediated Silencing in the Imprinted Gnas Cluster

Macro long non-coding RNAs (lncRNAs) play major roles in gene silencing in inprinted gene clusters. Within the imprinted Gnas cluster, the paternally expressed Nespas lncRNA downregulates its sense counterpart Nesp. To explore the mechanism of action of Nespas, we generated two new knock-in alleles...

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Publicat a:Noncoding RNA
Autors principals: Tibbit, Charlotte J., Williamson, Christine M., Mehta, Stuti, Ball, Simon T., Chotalia, Mita, Nottingham, Wade T., Eaton, Sally A., Quwailid, Mohamed M., Teboul, Lydia, Kelsey, Gavin, Peters, Jo
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5932550/
https://ncbi.nlm.nih.gov/pubmed/29861426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ncrna1030246
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