Uncoupling Antisense-Mediated Silencing and DNA Methylation in the Imprinted Gnas Cluster

There is increasing evidence that non-coding macroRNAs are major elements for silencing imprinted genes, but their mechanism of action is poorly understood. Within the imprinted Gnas cluster on mouse chromosome 2, Nespas is a paternally expressed macroRNA that arises from an imprinting control regio...

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Main Authors: Williamson, Christine M., Ball, Simon T., Dawson, Claire, Mehta, Stuti, Beechey, Colin V., Fray, Martin, Teboul, Lydia, Dear, T. Neil, Kelsey, Gavin, Peters, Jo
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2011
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3063750/
https://ncbi.nlm.nih.gov/pubmed/21455290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1001347
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