A Switch of G Protein-Coupled Receptor Binding Preference from Phosphoinositide 3-Kinase (PI3K)–p85 to Filamin A Negatively Controls the PI3K Pathway

Frequent oncogenic alterations occur in the phosphoinositide 3-kinase (PI3K) pathway, urging identification of novel negative controls. We previously reported an original mechanism for restraining PI3K activity, controlled by the somatostatin G protein-coupled receptor (GPCR) sst2 and involving a li...

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Bibliografiska uppgifter
Huvudupphovsmän: Najib, Souad, Saint-Laurent, Nathalie, Estève, Jean-Pierre, Schulz, Stefan, Boutet-Robinet, Elisa, Fourmy, Daniel, Lättig, Jens, Mollereau, Catherine, Pyronnet, Stéphane, Susini, Christiane, Bousquet, Corinne
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2012
Ämnen:
Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3295190/
https://ncbi.nlm.nih.gov/pubmed/22203038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.06252-11
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